diseases such as diabetes and atherosclerosis, cardiovascular diseases, and even chronic kidney disease (CKD) through low-grade systemic inflammation, although no causality can be drawn. CKD is an increasing problem worldwide, and has adverse effects on oral health. The main risk factors of CKD are diabetes mellitus (DM), hypertension and obesity. Diabetic nephropathy is the main reason for entering dialysis in Finland and cardiovascular diseases (CVD) play a crucial role in mortality among CKD patients. The hypotheses were that diabetic nephropathy patients have worse oral health than other CKD patients, at both predialysis and post-transplantation stages, and that salivary MMP-8 associates with worse oral inflammatory burden. The mortality rate was assumed to be higher among diabetic nephropathy patients. The main expected reason for death was cardiovascular disease.
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